Zhou_2022_MS

Study: Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

Publication: Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course (2022, Cell)

External link: SPIRE database (MAGs, genes and proteins including annotations)

Study accession: PRJEB32762

Last annotation change: 2025-10-31

Human Metadata

Cohort

88%
Cohort2
1895
Cohort1
 1295

MSSS

88%
0
 1600
0.86
 46
0.7
 45
0.64
 39
other values
 1456

administration

88%
Control
 1600
Untreated
 507
Subcutaneous
 485
Oral
 469
Infused
 129

allergies

85%
0
2042
1
 1021

allergy_specific

 28%
pollen
 47
Penicillin
 44
mites
 39
penicillin
 29
other values
 860

anxiety

85%
0
2689
1
 374

asthma

85%
0
2751
1
 312

breastfeeding

73%
1
1923
0
 728

children_number

 34%
2
 597
1
 458
3
 176
4
 21

csf_results

 21%
1
 534
3
 150
2
 99

depression

85%
0
2650
1
 413

diet_no_special_needs

88%
1
2568
0
 622

disease_course

88%
Control
 1600
RRMS
 1256
PPMS
 182
SPMS
 152

disease_course_control

88%
RRMS
 1256
Control_RRMS
 1254
Control_PMS
 346
PMS
 334

disease_duration

 44%
2
 97
4
 86
6
 85
3
 81
other values
 1237

dmt

 44%
1
 1083
0
 507

eating_disorder

85%
0
3035
1
 28

eczema

85%
0
2804
1
 259

edss

88%
0
2067
2
 183
1
 144
1.5
 142
other values
 654

education

85%
College/University Degree
 1122
Post-Graduate Education
 825
Some College/Technical Degree
 534
High School Graduate
 521
Some High School
 61

household

88%
7180029
 24
7180027
 17
7180002
 16
7180003
 16
other values
3117

manic_depression_bipolar

85%
0
3035
1
 28

ms_family

85%
0
2678
1
 383

nsaids

85%
0
1910
1
 1149

nsaids_specifics_frequency

 31%
ibuprofen 1/week
 58
ibuprofen 2/month
 55
ibuprofen 3/week
 43
ibuprofen, advil as needed
 35
other values
 954

occupation

84%
administrative
 242
Retired
 232
retired
 215
teacher
 73
other values
2285

ocd

85%
0
3031
1
 32

ocps_y_n

85%
0
2868
1
 191

otc_meds

84%
No
2120
Yes
 933

otc_number

84%
0
2120
1
 385
2
 232
3
 129
other values
 185

pets

85%
1
 1638
0
 1425

postpartum_depression

85%
0
2988
1
 75

probiotics

85%
0
2707
1
 352

recreational_drug

85%
0
2803
1
 256

relapse_number

88%
0
2958
1
 196
2
 21
3
 9
4
 4

roommates

 0%
2
 10
1
 10

rxmeds

84%
1
 1602
2
 1453
3
 2

rxmeds_number

84%
0
 1453
1
 598
2
 379
3
 219
other values
 397

site

100%
Buenos Aires
 1130
San Francisco
 869
Edinburgh
 738
New York
 413
other values
 450

smoke

85%
nonsmoker
 1745
formersmoker
 999
smoker
 315

spms_year

 4%
2015
 19
2016
 17
2010
 16
2007
 12
other values
 86

treatment_status

88%
Control
 1600
Treated
 1083
Untreated
 507

treatment_type

 37%
Control
 682
Off
 184
Gilenya
 138
Tecfidera
 106
other values
 250

treatments_control

88%
Control_Untreated
 518
Untreated
 507
Interferon
 285
Control_Interferon
 284
other values
 1596

type2diabetes

84%
0
2992
1
 62

vitamin.D..IU.

81%
0
 1716
200
 458
600
 293
400
 151
other values
 329

weight_change

85%
0
2517
1
 542

year_of_onset

 44%
2014
 95
2010
 92
2012
 78
2013
 76
other values
 1245

year_onset

 37%
Control
 682
2014
 54
2010
 52
2011
 44
other values
 530

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